Ophthalmology 119: 1024–1032.īrown DM, Campochiaro PA, Bhisitkul RB et al. (2012): Vascular endothelial growth factor Trap‐Eye for macular edema secondary to central retinal vein occlusion: six‐month results of the phase 3 COPERNICUS study. Graefes Arch Clin Exp Ophthalmol 248: 155–159.īoyer D, Heier J, Brown DM et al. Invest Ophthalmol Vis Sci 56: 5959.Īch T, Hoeh AE, Schaal KB, Scheuerle AF & Dithmar S (2010): Predictive factors for changes in macular edema in intravitreal bevacizumab therapy of retinal vein occlusion. (2015): Reproducibility of disorganization of the retinal inner layers (DRIL) grading across spectral domain optical coherence tomography (SDOCT) model and scan types in eyes with diabetic macular edema (DME). Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.Ībdulaal M, Lin MM, Ledesma M et al. Morphology on OCT explained only a modest part of functional loss in this patient cohort.īiomarker function morphology optical coherence tomography retinal vein occlusion. Of all parameters studied, only CST and age were consistently associated with worse BCVA in treatment-naïve RVO patients. Adjusted multiple R 2 for the respective group was 18.3%/26.3%/23.5%. A 10-year increase in age and female gender yielded a -2.0 and -2.5 letter decrease in the total cohort. In the total cohort, 100 µm increase in CST, SRF at CP and HRF at the central B-scan correlated with a difference of -3.2,+3.2 and -2.0 letters. In CRVO, a 100 µm increase in CST was associated with a loss of -3.4 letters. For BRVO, statistically significant correlations with BCVA were seen for a 100 µm increase in central subfield thickness (CST -3.1 letters), intraretinal cysts at centre point (CP +4.1), subretinal fluid (SRF) at CP (+3.0) and hyperreflective foci (HRF) at the central B-scan (-2.2). Included were 381/301 treatment-naïve patients with BRVO/CRVO. Main outcome measure was the estimated difference in Early Treatment Diabetic Retinopathy Study letters associated with each individual biomarker. The morphological grading was done manually, in the standardized setting of a reading centre. This was a cross-sectional posthoc analysis of OCT images that included RVO patients from two prospective, open-label, multicentre studies. We aimed to determine the correlation between optical coherence tomography (OCT)- and demographic features and baseline best corrected visual acuity (BCVA) in treatment-naïve patients with retinal vein occlusion (RVO).
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